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In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation

Riemenschneider, Markus J., Mueller, Wolf, Betensky, Rebecca A., Mohapatra, Gayatry and Louis, David N. (2005) In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation. The American journal of pathology 167 (5), pp. 1379-1387.

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Abstract

Deregulated integrin signaling is common in cancers, including glioblastoma. Integrin binding and growth factor receptor signaling activate focal adhesion kinase (FAK) and subsequently up-regulate extracellular regulated kinases (ERK-1/2), leading to cell-cycle progression and cell migration. Most studies of this pathway have used in vitro systems or tumor lysate-based approaches. We examined ...

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Item type:Article
Date:2005
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
10604475PubMed ID
10.1016/S0002-9440(10)61225-4DOI
Classification:
NotationType
Enzyme ActivationMESH
Extracellular Signal-Regulated MAP Kinases/metabolismMESH
Focal Adhesion Protein-Tyrosine Kinases/metabolismMESH
Gene Expression ProfilingMESH
Genes, erbB-1MESH
Glioblastoma/physiopathologyMESH
HumansMESH
ImmunohistochemistryMESH
In Situ Hybridization, FluorescenceMESH
Integrin beta Chains/metabolismMESH
Integrins/metabolismMESH
MaleMESH
Mitogen-Activated Protein Kinase 3/analysisMESH
Models, BiologicalMESH
Oligonucleotide Array Sequence AnalysisMESH
Paxillin/analysisMESH
RNA, Messenger/analysisMESH
Receptor, Epidermal Growth Factor/metabolismMESH
Receptor, Platelet-Derived Growth Factor alpha/metabolismMESH
Receptors, Growth Factor/metabolismMESH
Signal TransductionMESH
Up-RegulationMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29249
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