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Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias

Stummer, Walter ; Reulen, Hanns-Jürgen ; Meinel, Thomas ; Pichlmeier, Uwe ; Schumacher, Wiebke ; Tonn, Jörg-Christian ; Rohde, Veit ; Oppel, Falk ; Turowski, Bernd ; Woiciechowsky, Christian ; Franz, Kea ; Pietsch, Torsten



Abstract

Treatment bias was demonstrated regarding resection and second-line therapies. However, bias and imbalances were controllable in the cohorts available from the 5-aminolevulinic acid study so that the present data now provide Level 2b evidence (Oxford Centre for Evidence-based Medicine) that survival depends on complete resection of enhancing tumor in glioblastoma multiforme.


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