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Expression of hypoxia-inducible carbonic anhydrases in brain tumors

Proescholdt, Martin A. ; Mayer, Christina ; Kubitza, Marion ; Schubert, Thomas ; Liao, Shu-Yuan ; Stanbridge, Eric J. ; Ivanov, Sergey ; Oldfield, Edward H. ; Brawanski, Alexander ; Merrill, Marsha J.



Abstract

Malignant brain tumors exhibit distinct metabolic characteristics. Despite high levels of lactate, the intracellular pH of brain tumors is more alkaline than normal brain. Additionally, with increasing malignancy, brain tumors display intratumoral hypoxia. Carbonic anhydrase (CA) IX and XII are transmembrane isoenzymes that are induced by tissue hypoxia. They participate in regulation of pH ...

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