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Expression of hypoxia-inducible carbonic anhydrases in brain tumors

Proescholdt, Martin A., Mayer, Christina, Kubitza, Marion, Schubert, Thomas, Liao, Shu-Yuan, Stanbridge, Eric J., Ivanov, Sergey, Oldfield, Edward H., Brawanski, Alexander and Merrill, Marsha J. (2005) Expression of hypoxia-inducible carbonic anhydrases in brain tumors. Neuro-oncology 7 (4), pp. 465-475.

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Abstract

Malignant brain tumors exhibit distinct metabolic characteristics. Despite high levels of lactate, the intracellular pH of brain tumors is more alkaline than normal brain. Additionally, with increasing malignancy, brain tumors display intratumoral hypoxia. Carbonic anhydrase (CA) IX and XII are transmembrane isoenzymes that are induced by tissue hypoxia. They participate in regulation of pH ...

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Item type:Article
Date:2005
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
9770531PubMed ID
10.1215/S1152851705000025DOI
Classification:
NotationType
Blotting, WesternMESH
Brain Neoplasms/enzymologyMESH
Carbonic Anhydrases/biosynthesisMESH
Hemangioblastoma/etiologyMESH
HumansMESH
ImmunohistochemistryMESH
In Situ HybridizationMESH
von Hippel-Lindau Disease/complicationsMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29255
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