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Die Rolle des Proteins MIA/CD-RAP in der Chondrogenese

Schmid, Rainer (2014) Die Rolle des Proteins MIA/CD-RAP in der Chondrogenese. PhD, Universität Regensburg.

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Date of publication of this fulltext: 15 Jan 2014 13:38

Abstract (German)

Im Rahmen dieser Dissertation wurde zum besseren Verständnis der molekularen Vorgänge in der Chondrogenese die Rolle des Proteins MIA/CD-RAP mit Hilfe der MIA-knockout-Maus untersucht. Eine anfängliche Studie zum Auftreten von spontaner Osteoarthrose (OA) gab Hinweise auf eine verminderte Ausbildung von OA in MIA-knockout-Mäusen im Vergleich zu Wildtyp-Mäusen. Diese Beobachtung wurde in ...

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Translation of the abstract (English)

In this dissertation, the role of the protein MIA/CD-RAP was investigated with the help of the MIA-knockout-mouse to better understand the molecular events during chondrogenesis. An initial study on spontaneous emerging osteoarthritis (OA) revealed reduced OA in MIA-knockout-mice compared with wild type mice. This finding was further addressed in mouse models for cartilage destruction and ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:15 January 2014
Referee:Prof. Dr. Anja Katrin Bosserhoff and Prof. Dr. Klaus von der Mark and Prof. Dr. Ernst Tamm
Date of exam:19 December 2013
Institutions:Medicine > Lehrstuhl für Pathologie
Keywords:MIA/CD-RAP, p54nrb, YBX1, Promotoranalyse, Chondrogenese, Differenzierung, Proliferation, Knorpelregeneration, Cell Signaling
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29283
Owner only: item control page

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