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Molecular analysis of the neuroprotective role of Norrin for photoreceptors in the mammalian retina

Braunger, Barbara Maria (2014) Molecular analysis of the neuroprotective role of Norrin for photoreceptors in the mammalian retina. PhD, Universität Regensburg.

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Date of publication of this fulltext: 15 Jan 2014 14:09

Abstract (English)

Norrin is a secreted protein that binds to the frizzled-4 receptor to activate the canonical Wnt/β catenin signaling pathway. Norrin is critical for normal vascular development in the retina. In addition, Norrin has neuroprotective properties. The aim of the current thesis was to investigate if Norrin has neuroprotective effects on photoreceptor survival following light exposure, if this ...

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Translation of the abstract (German)

Norrin ist ein sezerniertes Signalprotein, das über eine Bindung an den Frizzled-4 Rezeptor den kanonischen Wnt/β-catenin Signalweg aktiviert. Während der Entwicklung ist Norrin essentiell für die Ausbildung eines intraretinalen Kapillargebiets in der Netzhaut. Weiterhin gibt es Hinweise für eine direkte neuroprotektive Wirkung von Norrin. Ziel der vorliegenden Doktorarbeit war es, zu ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:15 January 2014
Referee:Prof. Dr. Ernst R. Tamm and Prof. Dr. Bernhard Weber and Prof. Dr. Christian Grimm
Date of exam:18 December 2013
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Keywords:retina, photoreceptors, neuroprotection, Norrin
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29296
Owner only: item control page

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