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MGMT gene silencing and benefit from temozolomide in glioblastoma

Hegi, Monika E. ; Diserens, Annie-Claire ; Gorlia, Thierry ; Hamou, Marie-France ; de Tribolet, Nicolas ; Weller, Michael ; Kros, Johan M. ; Hainfellner, Johannes A. ; Mason, Warren ; Mariani, Luigi ; Bromberg, Jacoline E. C. ; Hau, Peter ; Mirimanoff, René O. ; Cairncross, J. Gregory ; Janzer, Robert C. ; Stupp, Roger


Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit.

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