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MGMT gene silencing and benefit from temozolomide in glioblastoma

Hegi, Monika E., Diserens, Annie-Claire, Gorlia, Thierry, Hamou, Marie-France, de Tribolet, Nicolas, Weller, Michael, Kros, Johan M., Hainfellner, Johannes A., Mason, Warren, Mariani, Luigi, Bromberg, Jacoline E. C., Hau, Peter, Mirimanoff, René O., Cairncross, J. Gregory, Janzer, Robert C. and Stupp, Roger (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma. The New England journal of medicine 352 (10), pp. 997-1003.

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Abstract

Patients with glioblastoma containing a methylated MGMT promoter benefited from temozolomide, whereas those who did not have a methylated MGMT promoter did not have such a benefit.


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Item type:Article
Date:2005
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
15938011PubMed ID
10.1056/NEJMoa043331DOI
Classification:
NotationType
Antineoplastic Agents, Alkylating/therapeutic useMESH
Brain Neoplasms/radiotherapyMESH
Chemotherapy, AdjuvantMESH
DNA MethylationMESH
Dacarbazine/therapeutic useMESH
Disease-Free SurvivalMESH
Gene SilencingMESH
Glioblastoma/radiotherapyMESH
HumansMESH
O(6)-Methylguanine-DNA Methyltransferase/geneticsMESH
Polymerase Chain ReactionMESH
Promoter Regions, GeneticMESH
Randomized Controlled Trials as TopicMESH
Survival AnalysisMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29305
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