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Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides

Hau, Peter ; Jachimczak, Piotr ; Bogdahn, Ulrich


Antisense oligodeoxynucleotides (AS-ODNs) have been widely used to determine gene function, validate drug targets and as novel therapeutics for human diseases. In this review, we describe the development of AS-ODNs, including their modifications, pharmacokinetics and toxicity in animal models and humans, and their preclinical and clinical development in the therapy of human high-grade gliomas. ...


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