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Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides

Hau, Peter, Jachimczak, Piotr and Bogdahn, Ulrich (2009) Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides. Expert review of anticancer therapy 9 (11), pp. 1663-1674.

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Abstract

Antisense oligodeoxynucleotides (AS-ODNs) have been widely used to determine gene function, validate drug targets and as novel therapeutics for human diseases. In this review, we describe the development of AS-ODNs, including their modifications, pharmacokinetics and toxicity in animal models and humans, and their preclinical and clinical development in the therapy of human high-grade gliomas. ...

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Item type:Article
Date:2009
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
19895249PubMed ID
10.1586/era.09.138DOI
Classification:
NotationType
AnimalsMESH
Brain Neoplasms/metabolismMESH
Clinical Trials as TopicMESH
Glioma/metabolismMESH
HumansMESH
Injections, IntralesionalMESH
Oligodeoxyribonucleotides/therapeutic useMESH
Oligonucleotides, Antisense/therapeutic useMESH
Thionucleotides/therapeutic useMESH
Transforming Growth Factor beta2/metabolismMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29306
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