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Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures

Rivera, Francisco J. ; Siebzehnrubl, Florian A. ; Kandasamy, Mahesh ; Couillard-Despres, Sebastien ; Caioni, Massimiliano ; Poehler, Anne-Maria ; Berninger, Benedikt ; Sandner, Beatrice ; Bogdahn, Ulrich ; Goetz, Magdalena ; Bluemcke, Ingmar ; Weidner, Norbert ; Aigner, Ludwig



Abstract

We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro. Here, we investigated if this pro-oligodendrogenic effect is maintained after cells have been transplanted onto rat hippocampal slice cultures, a CNS-organotypic environment. We first tested whether NPCs, that ...

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