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Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures

Rivera, Francisco J., Siebzehnrubl, Florian A., Kandasamy, Mahesh, Couillard-Despres, Sebastien, Caioni, Massimiliano, Poehler, Anne-Maria, Berninger, Benedikt, Sandner, Beatrice, Bogdahn, Ulrich, Goetz, Magdalena, Bluemcke, Ingmar, Weidner, Norbert and Aigner, Ludwig (2009) Mesenchymal stem cells promote oligodendroglial differentiation in hippocampal slice cultures. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 24 (3-4), pp. 317-324.

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Abstract

We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro. Here, we investigated if this pro-oligodendrogenic effect is maintained after cells have been transplanted onto rat hippocampal slice cultures, a CNS-organotypic environment. We first tested whether NPCs, that ...

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Item type:Article
Date:2009
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
19710546PubMed ID
10.1159/000233256DOI
Classification:
NotationType
AnimalsMESH
Antimetabolites/metabolismMESH
Bromodeoxyuridine/metabolismMESH
Cell Differentiation/physiologyMESH
FemaleMESH
Femur/cytologyMESH
Hippocampus/metabolismMESH
Mesenchymal Stromal Cells/metabolismMESH
Oligodendroglia/metabolismMESH
Organ Culture TechniquesMESH
RatsMESH
Rats, Inbred F344MESH
Rats, WistarMESH
Tibia/cytologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29308
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