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Rechallenge with temozolomide in patients with recurrent gliomas

Wick, Antje ; Pascher, Christina ; Wick, Wolfgang ; Jauch, Tanja ; Weller, Michael ; Bogdahn, Ulrich ; Hau, Peter



Abstract

Temozolomide (TMZ) is the standard of care for patients with newly diagnosed glioblastoma (GBM) as well as those with recurrent anaplastic glioma (AG) and GBM. It has become common practice to re-expose patients to TMZ who had been previously treated with TMZ, or to switch patients to alternative dosing regimens of TMZ when there are signs of relapse or progress on standard TMZ therapeutic ...

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