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A nuclear magnetic resonance biomarker for neural progenitor cells: is it all neurogenesis?

Ramm, Paul ; Couillard-Despres, Sebastien ; Plötz, Sonja ; Rivera, Francisco J. ; Krampert, Monika ; Lehner, Bernadette ; Kremer, Werner ; Bogdahn, Ulrich ; Kalbitzer, Hans R. ; Aigner, Ludwig


In vivo visualization of endogenous neural progenitor cells (NPCs) is crucial to advance stem cell research and will be essential to ensure the safety and efficacy of neurogenesis-based therapies. Magnetic resonance spectroscopic imaging (i.e., spatially resolved spectroscopy in vivo) is a highly promising technique by which to investigate endogenous neurogenesis noninvasively. A distinct feature ...


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