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Oligodendrogenesis of adult neural progenitors: differential effects of ciliary neurotrophic factor and mesenchymal stem cell derived factors

Rivera, Francisco J. ; Kandasamy, Mahesh ; Couillard-Despres, Sebastien ; Caioni, Massimiliano ; Sanchez, Rosario ; Huber, Christophe ; Weidner, Norbert ; Bogdahn, Ulrich ; Aigner, Ludwig



Abstract

The oligodendrogenic program of progenitor cells in the adult CNS follows a sequential process of progenitor proliferation, fate choice, determination, differentiation, maturation and survival. Previously, we described a soluble activity derived from mesenchymal stem cells that induces oligodendrogenesis in adult neural progenitor cells. Here, we hypothesized that ciliary neurotrophic factor ...

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