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Temozolomide preferentially depletes cancer stem cells in glioblastoma

Beier, Dagmar ; Röhrl, Stefanie ; Pillai, Deepu R. ; Schwarz, Stefanie ; Kunz-Schughart, Leoni A. ; Leukel, Petra ; Proescholdt, Martin A. ; Brawanski, Alexander ; Bogdahn, Ulrich ; Trampe-Kieslich, Ariane ; Giebel, Bernd ; Wischhusen, Jörg ; Reifenberger, Guido ; Hau, Peter ; Beier, Christoph P.


The prognosis of patients suffering from glioblastoma (GBM) is dismal despite multimodal therapy. Although chemotherapy with temozolomide may contain tumor growth for some months, invariable tumor recurrence suggests that cancer stem cells (CSC) maintaining these tumors persist. We have therefore investigated the effect of temozolomide on CD133(+) and CD133(-) GBM CSC lines. Although ...


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