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Temozolomide preferentially depletes cancer stem cells in glioblastoma

Beier, Dagmar, Röhrl, Stefanie, Pillai, Deepu R., Schwarz, Stefanie, Kunz-Schughart, Leoni A., Leukel, Petra, Proescholdt, Martin A., Brawanski, Alexander, Bogdahn, Ulrich, Trampe-Kieslich, Ariane, Giebel, Bernd, Wischhusen, Jörg, Reifenberger, Guido, Hau, Peter and Beier, Christoph P. (2008) Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer research 68 (14), pp. 5706-5715.

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Abstract

The prognosis of patients suffering from glioblastoma (GBM) is dismal despite multimodal therapy. Although chemotherapy with temozolomide may contain tumor growth for some months, invariable tumor recurrence suggests that cancer stem cells (CSC) maintaining these tumors persist. We have therefore investigated the effect of temozolomide on CD133(+) and CD133(-) GBM CSC lines. Although ...

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Item type:Article
Date:2008
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
19622770PubMed ID
10.1158/0008-5472.CAN-07-6878DOI
Classification:
NotationType
Antigens, CD/biosynthesisMESH
Antineoplastic Agents, Alkylating/pharmacologyMESH
Brain Neoplasms/pathologyMESH
Cell Line, TumorMESH
Cell SeparationMESH
Cells, CulturedMESH
DNA MethylationMESH
DNA Modification Methylases/pharmacologyMESH
DNA Repair Enzymes/pharmacologyMESH
Dacarbazine/pharmacologyMESH
Drug Resistance, NeoplasmMESH
Flow CytometryMESH
Glioblastoma/pathologyMESH
Glycoproteins/biosynthesisMESH
HumansMESH
Neoplastic Stem Cells/pathologyMESH
PeptidesMESH
Tumor Suppressor Proteins/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29317
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