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Procarbazine--a traditional drug in the treatment of malignant gliomas

Goerne, Rainer ; Bogdahn, Ulrich ; Hau, Peter



Abstract

The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. The compound is an antineoplastic agent with multiple sites of action. It inhibits incorporation of small DNA precursors, as well as RNA and protein synthesis. PCZ ...

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