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Procarbazine--a traditional drug in the treatment of malignant gliomas

Goerne, Rainer, Bogdahn, Ulrich and Hau, Peter (2008) Procarbazine--a traditional drug in the treatment of malignant gliomas. Current medicinal chemistry 15 (14), pp. 1376-1387.

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Abstract

The methylhydrazine derivative Procarbazine (PCZ) as monotherapy or in combination with CCNU and vincristine (PCV) was evaluated in a vast number of clinical trials and is still used in patients with high-grade and low-grade gliomas. The compound is an antineoplastic agent with multiple sites of action. It inhibits incorporation of small DNA precursors, as well as RNA and protein synthesis. PCZ ...

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Item type:Article
Date:2008
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
18537615PubMed ID
Classification:
NotationType
AnimalsMESH
Antineoplastic Agents/toxicityMESH
Antineoplastic Combined Chemotherapy Protocols/therapeutic useMESH
Brain Neoplasms/pathologyMESH
Clinical Trials as TopicMESH
Drug InteractionsMESH
Glioma/pathologyMESH
HumansMESH
Lomustine/therapeutic useMESH
Procarbazine/toxicityMESH
Vincristine/therapeutic useMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29318
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