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Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety

Schlingensiepen, Reimar ; Goldbrunner, Michael ; Szyrach, Mara N. I. ; Stauder, Gerhard ; Jachimczak, Piotr ; Bogdahn, Ulrich ; Schulmeyer, Frank ; Hau, Peter ; Schlingensiepen, Karl-Hermann



Abstract

Here, we provide first evidence that long-term continuous infusion of highly purified antisense phosphorothioate oligodeoxynucleotides (S-ODN) into brain parenchyma is well tolerated and thus highly suitable for in vivo application. AP 12009 is an S-ODN for the therapy of malignant glioma. It is directed against human transforming growth factor-beta (TGF-beta2) mRNA. In the clinical setting, AP ...

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