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Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety

Schlingensiepen, Reimar, Goldbrunner, Michael, Szyrach, Mara N. I., Stauder, Gerhard, Jachimczak, Piotr, Bogdahn, Ulrich, Schulmeyer, Frank, Hau, Peter and Schlingensiepen, Karl-Hermann (2005) Intracerebral and intrathecal infusion of the TGF-beta 2-specific antisense phosphorothioate oligonucleotide AP 12009 in rabbits and primates: toxicology and safety. Oligonucleotides 15 (2), pp. 94-104.

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Abstract

Here, we provide first evidence that long-term continuous infusion of highly purified antisense phosphorothioate oligodeoxynucleotides (S-ODN) into brain parenchyma is well tolerated and thus highly suitable for in vivo application. AP 12009 is an S-ODN for the therapy of malignant glioma. It is directed against human transforming growth factor-beta (TGF-beta2) mRNA. In the clinical setting, AP ...

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Item type:Article
Date:2005
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
15989424PubMed ID
10.1089/oli.2005.15.94DOI
Classification:
NotationType
AnimalsMESH
Brain Neoplasms/drug therapyMESH
Drug Evaluation, PreclinicalMESH
Glioma/drug therapyMESH
Injections, IntraventricularMESH
Injections, SpinalMESH
Macaca fascicularisMESH
MiceMESH
Oligonucleotides, Antisense/toxicityMESH
RabbitsMESH
RatsMESH
Rats, Sprague-DawleyMESH
Thionucleotides/toxicityMESH
Transforming Growth Factor beta/toxicityMESH
Transforming Growth Factor beta2MESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29338
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