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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Stupp, Roger, Mason, Warren P., van den Bent, Martin J., Weller, Michael, Fisher, Barbara, Taphoorn, Martin J. B., Belanger, Karl, Brandes, Alba A., Marosi, Christine, Bogdahn, Ulrich, Curschmann, Jürgen, Janzer, Robert C., Ludwin, Samuel K., Gorlia, Thierry, Allgeier, Anouk, Lacombe, Denis, Cairncross, J. Gregory, Eisenhauer, Elizabeth and Mirimanoff, René O. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. The New England journal of medicine 352 (10), pp. 987-996.

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Abstract

The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.


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Item type:Article
Date:2005
Additional Information (public):European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
15938012PubMed ID
10.1056/NEJMoa043330DOI
Classification:
NotationType
Adrenal Cortex Hormones/therapeutic useMESH
AdultMESH
AgedMESH
Antineoplastic Agents, Alkylating/therapeutic useMESH
Brain Neoplasms/radiotherapyMESH
Chemotherapy, AdjuvantMESH
Dacarbazine/therapeutic useMESH
Disease ProgressionMESH
FemaleMESH
Glioblastoma/radiotherapyMESH
HumansMESH
MaleMESH
Middle AgedMESH
Proportional Hazards ModelsMESH
Radiotherapy, Computer-Assisted/adverse effectsMESH
Survival AnalysisMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29339
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