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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Stupp, Roger ; Mason, Warren P. ; van den Bent, Martin J. ; Weller, Michael ; Fisher, Barbara ; Taphoorn, Martin J. B. ; Belanger, Karl ; Brandes, Alba A. ; Marosi, Christine ; Bogdahn, Ulrich ; Curschmann, Jürgen ; Janzer, Robert C. ; Ludwin, Samuel K. ; Gorlia, Thierry ; Allgeier, Anouk ; Lacombe, Denis ; Cairncross, J. Gregory ; Eisenhauer, Elizabeth ; Mirimanoff, René O.


The addition of temozolomide to radiotherapy for newly diagnosed glioblastoma resulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.

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