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Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected]

Hau, Peter ; Wise, Petra ; Bosserhoff, Anja-Katrin ; Blesch, Armin ; Jachimczak, Piotr ; Tschertner, Ines ; Bogdahn, Ulrich ; Apfel, Rainer


Melanoma-inhibiting activity/cartilage-derived retinoic acid-sensitive protein, a 11 kDa protein, is mainly expressed in cartilage during embryogenesis, and is related to invasion, metastasis, and immunomodulation of melanoma and glioma cells in vivo and in vitro. Here, we describe an alternative splice product of this gene termed melanoma-inhibiting activity (splice), lacking exon 2 of the ...


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