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MIA, a novel serum marker for progression of malignant melanoma

Bosserhoff, A. K. ; Lederer, M. ; Kaufmann, M. ; Hein, R. ; Stolz, W. ; Apfel, R. ; Bogdahn, U. ; Buettner, R.



Abstract

MIA was isolated previously as a small soluble protein secreted from malignant melanoma cell lines in vitro. Highly restricted expression patterns in melanocytic tumors were identified in vivo. We therefore quantitated serum levels of MIA protein by means of a non-radioactive ELISA and investigated whether MIA provides clinically relevant parameters in patients with malignant melanomas. Here we ...

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