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Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides

Jachimczak, P., Hessdörfer, B., Fabel-Schulte, K., Wismeth, C., Brysch, W., Schlingensiepen, K. H., Bauer, A., Blesch, A. and Bogdahn, U. (1996) Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides. International journal of cancer. Journal international du cancer 65 (3), pp. 332-337.

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Abstract

Transforming growth factors-beta 1 and -beta 2 (TGF-beta 1 and -beta 2) are important growth-regulatory proteins for astroglial neoplasms. We analyzed their role in tumor-cell proliferation in 12 glioma cell lines, employing phosphorothioate antisense oligodeoxynucleotides (S-ODNs, 14 mer), specifically targeted against the coding sequences of TGF-beta 1-mRNA and TGF-beta 2-mRNA. TGF-beta ...

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Item type:Article
Date:1996
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
8575854PubMed ID
10.1002/(SICI)1097-0215(19960126)65:3<332::AID-IJC10>3.0.CO;2-CDOI
Classification:
NotationType
Base SequenceMESH
Cell Division/drug effectsMESH
Glioma/pathologyMESH
HumansMESH
Molecular Sequence DataMESH
Oligonucleotides, Antisense/pharmacologyMESH
Thionucleotides/pharmacologyMESH
Transforming Growth Factor beta/metabolismMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29354
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