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Transforming growth factor-beta-mediated autocrine growth regulation of gliomas as detected with phosphorothioate antisense oligonucleotides

Jachimczak, P. ; Hessdörfer, B. ; Fabel-Schulte, K. ; Wismeth, C. ; Brysch, W. ; Schlingensiepen, K. H. ; Bauer, A. ; Blesch, A. ; Bogdahn, U.


Transforming growth factors-beta 1 and -beta 2 (TGF-beta 1 and -beta 2) are important growth-regulatory proteins for astroglial neoplasms. We analyzed their role in tumor-cell proliferation in 12 glioma cell lines, employing phosphorothioate antisense oligodeoxynucleotides (S-ODNs, 14 mer), specifically targeted against the coding sequences of TGF-beta 1-mRNA and TGF-beta 2-mRNA. TGF-beta ...


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