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1H NMR investigations of tumor spheroids grown from a human glioma biopsy or from a human malignant glioma cell line

Kotitschke, K. ; Tonn, J. C. ; Goldbrunner, R. ; Bogdahn, U. ; Haase, A.


Three-dimensional spherical aggregates of cells, grown from a permanent human malignant glioma cell line (multicellular GaMG spheroids) and from a human glioma biopsy (fragment spheroids), were investigated by 1H NMR spectroscopy. In addition, 1H NMR spectra of biopsy specimens immediately after explantation and of cell monolayers from primary passage and passage 5 were acquired and compared to ...


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