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Investigation of the 1H NMR visibility of lactate in different rat and human brain cells

Kotitschke, K. ; Schnackerz, K. D. ; Dringen, R. ; Bogdahn, U. ; Haase, A. ; von Kienlin, M.


In recent years, 1H MRS has been used in a number of studies to measure the lactate content of brain, and it is generally assumed that the methyl resonance at 1.3 ppm reflects the total amount of lactate present in the tissue. However, reduced NMR visibility of lactate has recently been reported for blood, heart and skeletal muscle as well as for bacteria. We have assessed the NMR visibility of ...


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