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High-resolution one- and two-dimensional 1H MRS of human brain tumor and normal glial cells

Kotitschke, K. ; Jung, H. ; Nekolla, S. ; Haase, A. ; Bauer, A. ; Bogdahn, U.



Abstract

Astrocytoma (WHO grade II, III), glioblastoma, malignant melanoma, and normal glial cell cultures, established from biopsies, were investigated by 1H MRS. At a 1H resonance frequency of 500 MHz (11.75 T) a high spectral resolution was achieved in 1D 1H spectra; in conjunction with 2D shift-correlated (COSY) MRS, resonances of alanine, aspartate, choline, creatine, glutamate, glutamine, ...

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