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In vitro studies on interaction of 4-hydroperoxy-ifosfamide and radiotherapy in malignant gliomas

Jäger, A. H. ; Bogdahn, U. ; Pfeufer, B. ; Richter, J. ; Apfel, R. ; Dekant, A.



Abstract

Drug-radiation multimodal chemotherapy for malignant brain tumor cells was stimulated in vitro by a recently developed computer program, based on evaluation of 3D-response surfaces and interaction isoboles. Three malignant glioma tumor cell cultures (HTZ17, 146 and 209 B) were sequentially treated in vitro by increasing doses of 4-hydroperoxy-ifosfamide, according to in vivo/in vitro ...

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