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Autocrine growth regulation in neuroectodermal tumors as detected with oligodeoxynucleotide antisense molecules

Behl, C. ; Winkler, J. ; Bogdahn, U. ; Meixensberger, J. ; Schlingensiepen, K. H. ; Brysch, W.



Abstract

The cell lines of three neuroectodermal tumors, two glioblastomas (HTZ-146, HTZ-17) and one melanoma (HTZ-19) were established and screened for the expression of growth factors by northern blotting and immunochemical methods. All three tumors were positive for platelet-derived growth factor- (PDGF-) A-, -B-chain, and basic fibroblast growth factor (bFGF) messenger ribonucleic acids. Cultured ...

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