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The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma

Jachimczak, P., Bogdahn, U., Schneider, J., Behl, C., Meixensberger, J., Apfel, R., Dörries, R., Schlingensiepen, K. H. and Brysch, W. (1993) The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma. Journal of neurosurgery 78 (6), pp. 944-951.

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Abstract

This in vitro study was aimed at restitution of transforming growth factor (TGF)-beta 2-mediated suppression of T-lymphocyte activation within malignant gliomas. In early-passage tumor cell cultures of two glioblastomas (HTZ-153 and HTZ-209) and one malignant astrocytoma classified as World Health Organization Grade III (HTZ-243), autologous peripheral blood mononuclear cells were activated by ...

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Item type:Article
Date:1993
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
8487077PubMed ID
10.3171/jns.1993.78.6.0944DOI
Classification:
NotationType
Antigens, CD/analysisMESH
Antigens, Neoplasm/analysisMESH
Blotting, NorthernMESH
Blotting, WesternMESH
Brain Neoplasms/immunologyMESH
Glioma/immunologyMESH
HumansMESH
Immunity, Cellular/drug effectsMESH
Immunocompromised Host/drug effectsMESH
Killer Cells, Lymphokine-Activated/immunologyMESH
Leukocytes, Mononuclear/immunologyMESH
Oligonucleotides, Antisense/pharmacologyMESH
PhenotypeMESH
RNA, Neoplasm/immunologyMESH
T-Lymphocytes, Cytotoxic/drug effectsMESH
Transforming Growth Factor beta/drug effectsMESH
Tumor Cells, Cultured/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29386
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