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The effect of transforming growth factor-beta 2-specific phosphorothioate-anti-sense oligodeoxynucleotides in reversing cellular immunosuppression in malignant glioma

Jachimczak, P. ; Bogdahn, U. ; Schneider, J. ; Behl, C. ; Meixensberger, J. ; Apfel, R. ; Dörries, R. ; Schlingensiepen, K. H. ; Brysch, W.



Abstract

This in vitro study was aimed at restitution of transforming growth factor (TGF)-beta 2-mediated suppression of T-lymphocyte activation within malignant gliomas. In early-passage tumor cell cultures of two glioblastomas (HTZ-153 and HTZ-209) and one malignant astrocytoma classified as World Health Organization Grade III (HTZ-243), autologous peripheral blood mononuclear cells were activated by ...

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