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Melanoma-inhibiting activity inhibits cell proliferation by prolongation of the S-phase and arrest of cells in the G2 compartment

Weilbach, F. X., Bogdahn, U., Poot, M., Apfel, R., Behl, C., Drenkard, D., Martin, R. and Hoehn, H. (1990) Melanoma-inhibiting activity inhibits cell proliferation by prolongation of the S-phase and arrest of cells in the G2 compartment. Cancer research 50 (21), pp. 6981-6986.

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Abstract

Autocrine-secreted melanoma tumor growth-inhibiting activity (MIA, approximately Mr 8000) was isolated from supernatants of a malignant melanoma cell line HTZ-19 dM, established from a central nervous system-melanoma metastasis. Cell cycle kinetic analysis performed with bromodeoxyuridine/Hoechst flow cytometry revealed a MIA-sensitive period at the G0/G1 to S traverse; MIA mediated prolongation ...

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Item type:Article
Date:1990
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
2208165PubMed ID
Classification:
NotationType
Cell Count/drug effectsMESH
Cell Cycle/drug effectsMESH
Cell Division/drug effectsMESH
Growth Inhibitors/pharmacologyMESH
HumansMESH
KineticsMESH
Melanoma/pathologyMESH
S Phase/drug effectsMESH
Tumor Cells, CulturedMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29391
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