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Vidarabin-monophosphate, BCNU, VM26--an in vitro comparative study of active agents in the treatment of malignant human brain tumours

Bogdahn, U., Zapf, J., Weber, H., Dünisch, G., Löbering, H. G., Martin, R. and Mertens, H. G. (1987) Vidarabin-monophosphate, BCNU, VM26--an in vitro comparative study of active agents in the treatment of malignant human brain tumours. British journal of cancer 55 (2), pp. 153-158.

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Abstract

BCNU (carmustine), VM26 (teniposide) and ARA-A5'P (vidarabin-monophosphate) were compared in their activity against 30 cell lines of primary (N = 21) and metastatic (N = 9) human brain tumours, which were characterized in tissue culture by cytochemical, immunological and cytogenetic criteria. In vivo achievable concentration-time products c X t were correlated with in vitro pharmacokinetic data ...

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Item type:Article
Date:1987
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
1182697PubMed ID
Classification:
NotationType
AdolescentMESH
AgedMESH
Arabinonucleotides/pharmacologyMESH
Brain Neoplasms/pathologyMESH
Carmustine/pharmacologyMESH
Cells, CulturedMESH
ChildMESH
Child, PreschoolMESH
Dose-Response Relationship, DrugMESH
Drug Evaluation, PreclinicalMESH
FemaleMESH
HumansMESH
KineticsMESH
MaleMESH
Middle AgedMESH
Neoplastic Stem Cells/drug effectsMESH
Podophyllotoxin/analogs & derivativesMESH
RNA, Neoplasm/biosynthesisMESH
Teniposide/pharmacologyMESH
Vidarabine Phosphate/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29393
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