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Interferon-beta in patients with low-grade astrocytomas--a phase I study

Bogdahn, U. ; Fleischer, B. ; Hilfenhaus, J. ; Röthig, H. J. ; Krauseneck, P. ; Mertens, H. G. ; Przuntek, H.



Abstract

In 3 patients with low-grade astrocytomas clinical pharmacology of interferon-beta (10(7) U/mg protein) was investigated. Interferon-beta with escalating dosage (2.3, 6.9, 23, 69 X 10(6) U/patient) was given to each patient in 4 infusions at weekly time intervals. In these patients dose-dependent plasma-levels of interferon-beta of up to 5800 IU/ml were achieved. Plasma concentrations showed a ...

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