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Interferon-beta in patients with low-grade astrocytomas--a phase I study

Bogdahn, U., Fleischer, B., Hilfenhaus, J., Röthig, H. J., Krauseneck, P., Mertens, H. G. and Przuntek, H. (1985) Interferon-beta in patients with low-grade astrocytomas--a phase I study. Journal of neuro-oncology 3 (2), pp. 125-130.

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Abstract

In 3 patients with low-grade astrocytomas clinical pharmacology of interferon-beta (10(7) U/mg protein) was investigated. Interferon-beta with escalating dosage (2.3, 6.9, 23, 69 X 10(6) U/patient) was given to each patient in 4 infusions at weekly time intervals. In these patients dose-dependent plasma-levels of interferon-beta of up to 5800 IU/ml were achieved. Plasma concentrations showed a ...

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Item type:Article
Date:1985
Institutions:Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Hirntumore (ZHT)
Identification Number:
ValueType
4031971PubMed ID
Classification:
NotationType
Astrocytoma/therapyMESH
Dose-Response Relationship, DrugMESH
Drug EvaluationMESH
HumansMESH
Interferon Type I/toxicityMESH
Killer Cells, Natural/immunologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:29396
Owner only: item control page
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