Nrf2 activates augmenter of liver regeneration (ALR) via antioxidant response element and links oxidative stress to liver regeneration.

URN to cite this document:: urn:nbn:de:bvb:355-epub-295125
DOI to cite this document:: 10.5283/epub.29512

Dayoub, Rania ; Vogel, Arndt ; Schuett, Jutta ; Lupke, Madeleine ; Spieker, Susannah M. ; Kettern, Nadja ; Hildt, Eberhardt ; Melter, Michael ; Weiss, Thomas S.

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Date of publication of this fulltext: 12 Feb 2014 10:58

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Abstract

Liver regeneration can be impaired by permanent oxidative stress and activation of nuclear factor erythroid 2–related factor 2 (Nrf2), known to regulate the cellular antioxidant response, and has been shown to improve the process of liver regeneration. A variety of factors regulate hepatic tissue regeneration, among them augmenter of liver regeneration (ALR), attained great attention as being ...