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The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension

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Mederle, Katharina ; Schweda, Frank ; Kattler, Veronika ; Doblinger, Elisabeth ; Keishi, Miyata ; Höcherl, Klaus ; Oike, Yuichi ; Castrop, Hajo
License: Creative Commons Attribution 3.0
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Date of publication of this fulltext: 12 Feb 2014 11:13


Introduction Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors, such as angiotensin II. The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro. We hypothesized that dysregulation of Arap1 may contribute to vascular hyporeactivity to ...


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