The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension

URN to cite this document:: urn:nbn:de:bvb:355-epub-295149
DOI to cite this document:: 10.5283/epub.29514

Mederle, Katharina ; Schweda, Frank ; Kattler, Veronika ; Doblinger, Elisabeth ; Keishi, Miyata ; Höcherl, Klaus ; Oike, Yuichi ; Castrop, Hayo

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Date of publication of this fulltext: 12 Feb 2014 11:13

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Abstract

Introduction Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors, such as angiotensin II. The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro. We hypothesized that dysregulation of Arap1 may contribute to vascular hyporeactivity to ...