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The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension

Mederle, Katharina, Schweda, Frank, Kattler, Veronika, Doblinger, Elisabeth, Keishi, Miyata, Höcherl, Klaus, Oike, Yuichi and Castrop, Hajo (2013) The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension. Critical Care 17, R130.

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Date of publication of this fulltext: 12 Feb 2014 11:13

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Abstract

Introduction Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors, such as angiotensin II. The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro. We hypothesized that dysregulation of Arap1 may contribute to vascular hyporeactivity to ...

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Item type:Article
Date:11 July 2013
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/cc12809DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29514
Owner only: item control page

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