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The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotension

URN to cite this document:
urn:nbn:de:bvb:355-epub-295149
Mederle, Katharina ; Schweda, Frank ; Kattler, Veronika ; Doblinger, Elisabeth ; Keishi, Miyata ; Höcherl, Klaus ; Oike, Yuichi ; Castrop, Hajo
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Date of publication of this fulltext: 12 Feb 2014 11:13


Abstract

Introduction Hypotension in septic patients results from hypovolemia, vasodilatation and hyporeactivity to vasoconstrictors, such as angiotensin II. The AT1 receptor-associated protein 1 (Arap1) is expressed in vascular smooth muscle cells and increases the surface expression of the AT1-receptor in vitro. We hypothesized that dysregulation of Arap1 may contribute to vascular hyporeactivity to ...

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