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IL-13 signaling via IL-13Ralpha2 triggers TGF-beta1-dependent allograft fibrosis

URN to cite this document:
urn:nbn:de:bvb:355-epub-295177
Brunner, Stefan ; Schichl, Gabriela ; Kesselring, Rebecca ; Martin, Maria ; Balam, Saido ; Schlitt, Hans-Jürgen ; Geissler, Edward K. ; Fichtner-Feigl, Stefan
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Date of publication of this fulltext: 12 Feb 2014 11:45


Abstract

Background Allograft fibrosis still remains a critical problem in transplantation, including heart transplantation. The IL-13/TGF-β1 interaction has previously been identified as a key pathway orchestrating fibrosis in different inflammatory immune disorders. Here we investigate if this pathway is also responsible for allograft fibrosis and if interference with the IL-13/TGF-β1 interaction ...

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