CD137 Facilitates the Resolution of Acute DSS-Induced Colonic Inflammation in Mice

URN to cite this document:: urn:nbn:de:bvb:355-epub-295199
DOI to cite this document:: 10.5283/epub.29519

Martinez Gomez, Julia M. ; Lieping, Chen ; Schwarz, Herbert ; Karrasch, Thomas

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Date of publication of this fulltext: 12 Feb 2014 11:57

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Abstract

Background: CD137 and its ligand (CD137L) are potent immunoregulatory molecules that influence activation, proliferation, differentiation and cell death of leukocytes. Expression of CD137 is upregulated in the lamina propria cells of Crohn's disease patients. Here, the role of CD137 in acute Dextran-Sodium-Sulfate (DSS)-induced colitis in mice was examined. Methods: We induced acute large bowel ...