Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma

URN to cite this document:: urn:nbn:de:bvb:355-epub-295328
DOI to cite this document:: 10.5283/epub.29532

Bedal, Konstanze B. ; Grässel, Susanne ; Oefner, Peter J.

; Reinders, Jörg ; Reichert, Torsten E. ; Bauer, Richard

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Date of publication of this fulltext: 12 Feb 2014 12:39

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Abstract

Collagen XVI belongs to the family of fibril-associated collagens with interrupted triple helices (FACIT). It is overexpressed during the progression of oral squamous cell carcinoma (OSCC). The present data show a strong collagen XVI-dependent induction of MMP9 and an increase in OSCC cell invasion. We found activated integrin-linked kinase (ILK) in a complex with kindlin-1 and activation of ...