Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-295328

Bedal, Konstanze B., Grässel, Susanne, Oefner, Peter J., Reinders, Jörg, Reichert, Torsten E. und Bauer, Richard (2014) Collagen XVI induces expression of MMP9 via modulation of AP-1 transcription factors and facilitates invasion of oral squamous cell carcinoma. Plos One 9 (1), e86777.

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Zusammenfassung

Collagen XVI belongs to the family of fibril-associated collagens with interrupted triple helices (FACIT). It is overexpressed during the progression of oral squamous cell carcinoma (OSCC). The present data show a strong collagen XVI-dependent induction of MMP9 and an increase in OSCC cell invasion. We found activated integrin-linked kinase (ILK) in a complex with kindlin-1 and activation of ...

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