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Adipose tissue-derived Stem Cell (ASC) secreted IGF-1 protects myoblasts from the negative effect of Myostatin

Gehmert, Sebastian, Wenzel, Carina, Loibl, Markus, Brockhoff, Gero, Huber, Michaela, Krutsch, Werner, Nerlich, Michael, Gosau, Martin, Klein, Silvan, Schreml, Stephan, Prantl, Lukas and Gehmert, Sanga (2014) Adipose tissue-derived Stem Cell (ASC) secreted IGF-1 protects myoblasts from the negative effect of Myostatin. BioMed Research International 2014.

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Date of publication of this fulltext: 12 Feb 2014 12:41

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Abstract

Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Muscular Dystrophy (DMD). But the protective effect of stem cell secreted IGF-1 on ...

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Item type:Article
Date:23 January 2014
Institutions:UNSPECIFIED
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1155/2014/129048DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29533
Owner only: item control page

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