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Adipose tissue-derived Stem Cell (ASC) secreted IGF-1 protects myoblasts from the negative effect of Myostatin

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Gehmert, Sebastian ; Wenzel, Carina ; Loibl, Markus ; Brockhoff, Gero ; Huber, Michaela ; Krutsch, Werner ; Nerlich, Michael ; Gosau, Martin ; Klein, Silvan ; Schreml, Stephan ; Prantl, Lukas ; Gehmert, Sanga
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 12 Feb 2014 12:41


Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Muscular Dystrophy (DMD). But the protective effect of stem cell secreted IGF-1 on ...


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