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The RNA polymerase trigger loop functions in all three phases of the transcription cycle

Fouqueau, Thomas, Zeller, Mirijam Elisabeth, Cheung, Alan C., Cramer, Patrick and Thomm, Michael (2013) The RNA polymerase trigger loop functions in all three phases of the transcription cycle. Nucleic Acids Research.

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Abstract

The trigger loop (TL) forms a conserved element in the RNA polymerase active centre that functions in the elongation phase of transcription. Here, we show that the TL also functions in transcription initiation and termination. Using recombinant variants of RNA polymerase from Pyrococcus furiosus and a reconstituted transcription system, we demonstrate that the TL is essential for initial RNA ...

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Item type:Article
Date:3 June 2013
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Mikrobiologie > Prof. Dr. Michael Thomm
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1093/nar/gkt433DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29541
Owner only: item control page

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