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Basophile Granulozyten als Regulatoren der CD4+ T-Zellfunktion

Hermann, Fabian Johannes (2015) Basophile Granulozyten als Regulatoren der CD4+ T-Zellfunktion. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Feb 2015 17:29

Abstract (German)

Basophile Granulozyten wurden zunächst als reine Effektorzellpopulation charakterisiert; in dieser Arbeit konnte jedoch gezeigt werden, dass Basophile Granulozyten in vitro in der Lage sind, sowohl die syngene, als auch die Allogen-induzierte Proliferation von CD4+ T-Zellen zu unterdrücken. Basophile Granulozyten inhibieren die T-Zellproliferation unabhängig von Antigenpräsentation über MHC ...

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Translation of the abstract (English)

In this study, we demonstrate that murine basophils are able to inhibit syngeneic and allogeneic proliferation of CD4+ T cells. This effect is independent of Fas and MHC II contact, but dependent on the soluble factors interleukin (IL)-4 and IL-6. In accordance to this, neutralization of IL-4 re-established the T cell proliferation mediated by basophils. Thus we are describing a new function of ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:26 February 2015
Referee:Prof. Dr. Matthias Mack
Date of exam:18 February 2014
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Keywords:Basophils, Basophile Granulozyten, GvHD, Graft-versus-host-disease, Spender-Wirt-Reaktion, MLR, CD4, T-Zellen, T cells, syngeneic T cell proliferation, Zytokine, cytokines, Interleukin 4, Interleukin 6, IL-4, IL-6, T cell proliferation, T-zellproliferation
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29566
Owner only: item control page

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