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Site-specific immune response to implanted gliomas

Proescholdt, M. A. ; Merrill, M. J. ; Ikejiri, B. ; Walbridge, S. ; Akbasak, A. ; Jacobson, S. ; Oldfield, E. H.


Abstract

Object. Immunotherapy for glioblastoma has been uniformly ineffective. The immunological environment of the brain, with its low expression of major histocompatibility complex (MHC) molecules and limited access for inflammatory cells and humoral immune effectors due to the blood—brain barrier (BBB), may contribute to the failure of immunotherapy. The authors hypothesize that brain tumors are ...

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