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Characterization of the anti-inflammatory activity of enones based on the evaluation of their heme oxygenase-1 and inducible NO synthase activity

URN to cite this document:
urn:nbn:de:bvb:355-epub-297733
Rücker, Hannelore-Maria
Date of publication of this fulltext: 09 Apr 2015 14:01


Abstract (English)

To fight chronic inflammation in autoimmune diseases such as rheumatic arthritis and multiple sclerosis or cancer is an exigency. Therefore the inhibition of proinflammatory proteins such as inducible NO-synthase (iNOS) and the activation of anti-inflammatory proteins such as heme oxygenase-1 (HO-1) are important measures to be addressed. Many natural products and synthetic compounds with an ...

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Translation of the abstract (German)

Neue Konzepte zur Therapie von chronisch-entzündlichen Krankheiten oder Autoimmun-Erkrankungen wie Multiple Sklerose und rheumatoide Arthritis sowie bei Krebserkrankungen stellen einen bedeutenden Beitrag zur medizinischen Wirkstoffforschung dar. Als wichtige Zielstrukturen zur Entwicklung neuer Entzündungshemmer spielt auf der einen Seite die Inhibierung der proinflammatorischen induzierbaren ...

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