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Monocyte to Macrophage Differentiation Goes along with Modulation of the Plasmalogen Pattern through Transcriptional Regulation

URN to cite this document:
urn:nbn:de:bvb:355-epub-298269
Wallner, Stefan ; Grandl, Margot ; Konovalova, Tatiana ; Sigrüner, Alexander ; Kopf, Thomas ; Peer, Markus ; Orsó, Evelyn ; Liebisch, Gerhard ; Schmitz, Gerd
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Date of publication of this fulltext: 17 Apr 2014 11:07


Abstract

Dysregulation of monocyte-macrophage differentiation is a hallmark of vascular and metabolic diseases and associated with persistent low grade inflammation. Plasmalogens represent ether lipids that play a role in diabesity and previous data show diminished plasmalogen levels in obese subjects. We therefore analyzed transcriptomic and lipidomic changes during monocyte-macrophage differentiation in vitro using a bioinformatic approach.


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