Go to content
UR Home

Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients

Werner-Klein, Melanie, Proske, Judith, Werno, Christian, Schneider, Katharina, Hofmann, Hans-Stefan, Rack, Brigitte, Buchholz, Stefan, Ganzer, Roman, Blana, Andreas, Sellbach-Göbel, Birgit, Nitsche, Ulrich, Männel, Daniela N. and Klein, Christoph A. (2014) Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients. PLoS ONE 9 (5), e97860.

[img]
Preview
PDF
Download (1MB)
Date of publication of this fulltext: 19 May 2014 09:20

at publisher (via DOI)

Other URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0097860


Abstract

Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we explore a novel way to generate cancer models with an autologous humanized immune system. We demonstrate that hematopoietic stem and progenitor cells ...

plus


Export bibliographical data



Item type:Article
Date:15 March 2014
Institutions:Medicine > Lehrstuhl für Immunologie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1371/journal.pone.0097860DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:29964
Owner only: item control page

Downloads

Downloads per month over past year

  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons