Werner-Klein, Melanie, Proske, Judith, Werno, Christian, Schneider, Katharina, Hofmann, Hans-Stefan, Rack, Brigitte, Buchholz, Stefan, Ganzer, Roman, Blana, Andreas, Sellbach-Göbel, Birgit, Nitsche, Ulrich, Männel, Daniela N. and Klein, Christoph A. (2014) Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients. PLoS ONE 9 (5), e97860.
| PDF Download (1MB) |
Other URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0097860
Abstract
Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we explore a novel way to generate cancer models with an autologous humanized immune system. We demonstrate that hematopoietic stem and progenitor cells ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 15 March 2014 | ||||
| Institutions: | Medicine > Lehrstuhl für Immunologie | ||||
| Projects: | Open Access Publizieren (DFG) | ||||
| Identification Number: |
| ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 29964 |
Download Statistics