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Immune Humanization of Immunodeficient Mice Using Diagnostic Bone Marrow Aspirates from Carcinoma Patients

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Werner-Klein, Melanie ; Proske, Judith ; Werno, Christian ; Schneider, Katharina ; Hofmann, Hans-Stefan ; Rack, Brigitte ; Buchholz, Stefan ; Ganzer, Roman ; Blana, Andreas ; Seelbach-Göbel, Birgit ; Nitsche, Ulrich ; Männel, Daniela N. ; Klein, Christoph A.
Date of publication of this fulltext: 19 May 2014 09:20


Tumor xenografts in immunodeficient mice, while routinely used in cancer research, preclude studying interactions of immune and cancer cells or, if humanized by allogeneic immune cells, are of limited use for tumor-immunological questions. Here, we explore a novel way to generate cancer models with an autologous humanized immune system. We demonstrate that hematopoietic stem and progenitor cells ...


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