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Differential angiogenic properties of lithium chloride in vitro and in vivo

URN to cite this document:
urn:nbn:de:bvb:355-epub-300177
Ohlmann, Andreas ; Tamm, Ernst R. ; Knobloch, Verena ; Müller, Birgit ; Zeilbeck, Ludwig Franz
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Date of publication of this fulltext: 26 Feb 2015 17:17


Abstract

Wnt/β-catenin signaling induced by the Norrin/Frizzled-4 pathway has been shown to improve capillary repair following oxygen induced retinopathy (OIR) in the mouse, a model for retinopathy of prematurity. Here we investigated if treatment with the monovalent cation lithium that has been shown to augment Wnt/β-catenin signaling in vitro and in vivo has similar effects. In cultured human ...

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