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The Natural Chemopreventive Agent Sulforaphane Inhibits STAT5 Activity

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Prinz, Sophia ; Unser, Samy ; Rascle, Anne
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 09 Jul 2014 12:09


Signal transducer and activator of transcription STAT5 is an essential mediator of cytokine, growth factor and hormone signaling. While its activity is tightly regulated in normal cells, its constitutive activation directly contributes to oncogenesis and is associated to a number of hematological and solid tumor cancers. We previously showed that deacetylase inhibitors can inhibit STAT5 ...


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