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Strong reduction of AGO2 expression in melanoma and cellular consequences

Völler, D., Reinders, Jörg, Meister, Gunter and Bosserhoff, Anja-Katrin (2013) Strong reduction of AGO2 expression in melanoma and cellular consequences. British Journal of Cancer 109, pp. 3116-3124.

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Abstract

Background: Processing of microRNAs (miRNAs) is a highly controlled process. Deregulation of miRNA expression was observed in several types of cancer but changes in the miRNA-processing enzymes have not been analysed until today. In this study, we analysed Argonaute2 (AGO2, EIF2C2), as one main factor of the miRNA processing ensemble, in the context of cancer development, especially in ...

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Item type:Article
Date:29 October 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Identification Number:
ValueType
10.1038/bjc.2013.646DOI
Keywords:malignant melanoma; AGO2; RNAi; miRNA; siRNA; shRNA; cJun
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30514
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