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Strong reduction of AGO2 expression in melanoma and cellular consequences

Völler, D. ; Reinders, Jörg ; Meister, Gunter ; Bosserhoff, Anja-Katrin



Abstract

Background: Processing of microRNAs (miRNAs) is a highly controlled process. Deregulation of miRNA expression was observed in several types of cancer but changes in the miRNA-processing enzymes have not been analysed until today. In this study, we analysed Argonaute2 (AGO2, EIF2C2), as one main factor of the miRNA processing ensemble, in the context of cancer development, especially in ...

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