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DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.

URN to cite this document:
Aryee, Martin J ; Liu, Wennuan ; Engelmann, Julia C. ; Nuhn, Philipp ; Gurel, Meltem ; Haffner, Michael C ; Esopi, David ; Irizarry, Rafael A ; Getzenberg, Robert H ; Nelson, William G ; Luo, Jun ; Xu, Jianfeng ; Isaacs, William B ; Bova, G Steven ; Yegnasubramanian, Srinivasan
Date of publication of this fulltext: 05 Aug 2014 09:18


Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially heritable, they can also be dynamically altered. Given this potential for plasticity, the degree to which epigenetic changes can be subject to selection and act as drivers of neoplasia has been questioned. We carried out genome-scale analyses ...


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