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DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases.

Aryee, Martin J, Liu, Wennuan, Engelmann, Julia C., Nuhn, Philipp, Gurel, Meltem, Haffner, Michael C, Esopi, David, Irizarry, Rafael A, Getzenberg, Robert H, Nelson, William G, Luo, Jun, Xu, Jianfeng, Isaacs, William B, Bova, G Steven and Yegnasubramanian, Srinivasan (2013) DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Science translational medicine 5 (169), 169ra10.

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Abstract

Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigenetic marks, including DNA methylation, are potentially heritable, they can also be dynamically altered. Given this potential for plasticity, the degree to which epigenetic changes can be subject to selection and act as drivers of neoplasia has been questioned. We carried out genome-scale analyses ...

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Item type:Article
Date:23 January 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
18337604PubMed ID
10.1126/scitranslmed.3005211DOI
Classification:
NotationType
AllelesMESH
Clone CellsMESH
DNA Methylation/geneticsMESH
DNA-Binding Proteins/geneticsMESH
Epigenesis, GeneticMESH
Gene Expression Regulation, NeoplasticMESH
Genetic HeterogeneityMESH
GenomicsMESH
HumansMESH
MaleMESH
Neoplasm MetastasisMESH
Polymorphism, Single Nucleotide/geneticsMESH
Prostatic Neoplasms/pathologyMESH
Protein Structure, TertiaryMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30526
Owner only: item control page

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