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Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

Krentz, S. ; Hof, J. ; Mendioroz, A. ; Vaggopoulou, R. ; Dörge, P. ; Lottaz, Claudio ; Engelmann, Julia ; Groeneveld, T. W. L. ; Körner, G. ; Seeger, K. ; Hagemeier, C. ; Henze, G. ; Eckert, C. ; von Stackelberg, A. ; Kirschner-Schwabe, R.


Despite risk-adapted treatment, survival of children with relapse of acute lymphoblastic leukemia (ALL) remains poor compared with that of patients with initial diagnosis of ALL. Leukemia-associated genetic alterations may provide novel prognostic factors to refine present relapse treatment strategies. Therefore, we investigated the clinical relevance of 13 recurrent genetic alterations in 204 ...


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