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Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia

Krentz, S., Hof, J., Mendioroz, A., Vaggopoulou, R., Dörge, P., Lottaz, Claudio, Engelmann, Julia, Groeneveld, T. W. L., Körner, G., Seeger, K., Hagemeier, C., Henze, G., Eckert, C., Stackelberg, A. von and Kirschner-Schwabe, R. (2013) Prognostic value of genetic alterations in children with first bone marrow relapse of childhood B-cell precursor acute lymphoblastic leukemia. Leukemia 27 (2), pp. 295-304.

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Abstract

Despite risk-adapted treatment, survival of children with relapse of acute lymphoblastic leukemia (ALL) remains poor compared with that of patients with initial diagnosis of ALL. Leukemia-associated genetic alterations may provide novel prognostic factors to refine present relapse treatment strategies. Therefore, we investigated the clinical relevance of 13 recurrent genetic alterations in 204 ...

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Item type:Article
Date:27 February 2013
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
22699455PubMed ID
10.1038/leu.2012.155DOI
Classification:
NotationType
Bone Marrow Neoplasms/mortalityMESH
ChildMESH
DNA, Neoplasm/geneticsMESH
FemaleMESH
Follow-Up StudiesMESH
Gene DeletionMESH
HumansMESH
Ikaros Transcription Factor/geneticsMESH
MaleMESH
Mutation/geneticsMESH
Neoplasm Recurrence, Local/mortalityMESH
Polymerase Chain ReactionMESH
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathologyMESH
PrognosisMESH
Risk FactorsMESH
Survival RateMESH
Tumor Markers, Biological/geneticsMESH
Tumor Suppressor Protein p53/geneticsMESH
Keywords:Bone Marrow Neoplasms, diagnosis/genetics/mortality; Child; DNA, Neoplasm, genetics; Female; Follow-Up Studies; Gene Deletion; Humans; Ikaros Transcription Factor, genetics; Male; Mutation, genetics; Neoplasm Recurrence, Local, diagnosis/genetics/mortality; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, genetics/mortality/pathology; Prognosis; Risk Factors; Survival Rate; Tumor Markers, Biological, genetics; Tumor Suppressor Protein p53, genetics
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30572
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