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Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system

Lowin, Torsten, Zhu, Wentao, Dettmer-Wilde, Katja and Straub, Rainer H. (2012) Cortisol-mediated adhesion of synovial fibroblasts is dependent on the degradation of anandamide and activation of the endocannabinoid system. Arthritis and rheumatism 64 (12), pp. 3867-3876.

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Abstract

OBJECTIVE: In rheumatoid arthritis (RA) synovial fluid, levels of the endocannabinoids anandamide (AEA) and 2-arachidonylglycerol are elevated. Since synovial fibroblasts (SFs) possess all of the enzymes necessary for endocannabinoid synthesis, it is likely that these cells contribute significantly to elevated endocannabinoid levels. While glucocorticoids initiate endocannabinoid synthesis in ...

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Item type:Article
Date:December 2012
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
22933357PubMed ID
10.1002/art.37684DOI
Classification:
NotationType
AgedMESH
Amidohydrolases/metabolismMESH
Arachidonic Acids/metabolismMESH
Arthritis, Rheumatoid/pathologyMESH
Cell Adhesion/drug effectsMESH
Cells, CulturedMESH
Cyclooxygenase 2/metabolismMESH
Dose-Response Relationship, DrugMESH
Endocannabinoids/metabolismMESH
FemaleMESH
Fibroblasts/pathologyMESH
Fibronectins/metabolismMESH
HumansMESH
Hydrocortisone/pharmacologyMESH
MaleMESH
Middle AgedMESH
Osteoarthritis, Knee/pathologyMESH
Polyunsaturated Alkamides/metabolismMESH
Synovial Membrane/pathologyMESH
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30580
Owner only: item control page
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