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GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Amann, Thomas, Maegdefrau, Ulrike, Hartmann, Arndt, Agaimy, Abbas, Marienhagen, Jörg, Weiss, Thomas S., Stoeltzing, Oliver, Warnecke, Christina, Schölmerich, Jürgen, Oefner, Peter J., Kreutz, Marina, Bosserhoff, Anja-Katrin and Hellerbrand, Claus (2009) GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. The American journal of pathology 174 (4), pp. 1544-1552.

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Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 (GLUT1) gene encodes a key rate-limiting factor in glucose transport into cancer cells. However, its expression level and functional significance in hepatocellular cancer (HCC) are still disputed. Therefore, we aimed to analyze the expression and function of the GLUT1 gene in cases ...


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Item type:Article
Date:April 2009
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin I
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Pathologie
Medicine > Abteilung für Nuklearmedizin
Identification Number:
19286567PubMed ID
Blotting, WesternMESH
Carcinoma, Hepatocellular/pathologyMESH
Cell Hypoxia/geneticsMESH
Cell Line, TumorMESH
Cell Movement/geneticsMESH
Cell ProliferationMESH
Flow CytometryMESH
Gene Expression Regulation, NeoplasticMESH
Glucose Transporter Type 1/geneticsMESH
Hypoxia-Inducible Factor 1, alpha Subunit/metabolismMESH
Liver Neoplasms/pathologyMESH
RNA, Messenger/analysisMESH
Reverse Transcriptase Polymerase Chain ReactionMESH
Tissue Array AnalysisMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:30666
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