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GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis

Amann, Thomas ; Maegdefrau, Ulrike ; Hartmann, Arndt ; Agaimy, Abbas ; Marienhagen, Jörg ; Weiss, Thomas S. ; Stoeltzing, Oliver ; Warnecke, Christina ; Schölmerich, Jürgen ; Oefner, Peter J. ; Kreutz, Marina ; Bosserhoff, Anja-Katrin ; Hellerbrand, Claus



Abstract

Accelerated glycolysis is one of the biochemical characteristics of cancer cells. The glucose transporter isoform 1 (GLUT1) gene encodes a key rate-limiting factor in glucose transport into cancer cells. However, its expression level and functional significance in hepatocellular cancer (HCC) are still disputed. Therefore, we aimed to analyze the expression and function of the GLUT1 gene in cases ...

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