Are applied growth factors able to mimic the positive effects of mesenchymal stem cells on the regeneration of meniscus in the avascular zone?

URN to cite this document:: urn:nbn:de:bvb:355-epub-306950
DOI to cite this document:: 10.5283/epub.30695

Zellner, Johannes ; Taeger, Christian Dirk ; Schaffer, Markus ; Roldan, J. Camilo ; Loibl, Markus ; Müller, Michael ; Berner, Arne ; Krutsch, Werner ; Huber, Michaela ; Kujat, Richard ; Nerlich, Michael ; Angele, Peter

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Date of publication of this fulltext: 20 Aug 2014 05:09

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Abstract

(PRP) or Bone Morphogenic Protein 7 (BMP7) are in the focus of interest. In this study the effects of PRP and BMP7 on the regeneration of avascular meniscal defects were evaluated. In vitro analysis showed that PRP secretes multiple growth factors over a period of 8 days. BMP7 enhances the collagen II deposition in an aggregate culture model of MSCs. However applied to different shaped meniscal ...