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Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina

Pannike, T., Frommherz, I., Biedermann, B., Wagner, L., Sauer, K., Ulbricht, E., Härtig, W., Krügel, U., Ueberham, U., Arendt, T., Illes, P., Bringmann, A., Reichenbach, A. and Grosche, Antje (2014) Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina. Cell Death and Disease 2014 (5), e1353.

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Date of publication of this fulltext: 20 Aug 2014 05:51

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Other URL: http://www.nature.com/cddis/journal/v5/n7/full/cddis2014317a.html


Abstract

Gliosis of retinal Müller glial cells may have both beneficial and detrimental effects on neurons. To investigate the role of purinergic signaling in ischemia-induced reactive gliosis, transient retinal ischemia was evoked by elevation of the intraocular pressure in wild-type (Wt) mice and in mice deficient in the glia-specific nucleotide receptor P2Y1 (P2Y1 receptor-deficient (P2Y1R-KO)). While ...

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Item type:Article
Date:31 July 2014
Institutions:Medicine > Lehrstuhl für Humangenetik
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1038/cddis.2014.317DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:30696
Owner only: item control page

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