Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina

URN zum Zitieren dieses Dokuments: urn:nbn:de:bvb:355-epub-306967

Pannike, T., Frommherz, I., Biedermann, B., Wagner, L., Sauer, K., Ulbricht, E., Härtig, W., Krügel, U., Ueberham, U., Arendt, T., Illes, P., Bringmann, A., Reichenbach, A. und Grosche, Antje (2014) Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina. Cell Death and Disease 2014 (5), e1353.

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Andere URL zum Volltext: http://www.nature.com/cddis/journal/v5/n7/full/cddis2014317a.html

Zusammenfassung

Gliosis of retinal Müller glial cells may have both beneficial and detrimental effects on neurons. To investigate the role of purinergic signaling in ischemia-induced reactive gliosis, transient retinal ischemia was evoked by elevation of the intraocular pressure in wild-type (Wt) mice and in mice deficient in the glia-specific nucleotide receptor P2Y1 (P2Y1 receptor-deficient (P2Y1R-KO)). While ...

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