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Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina

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Pannike, T. ; Frommherz, I. ; Biedermann, B. ; Wagner, L. ; Sauer, K. ; Ulbricht, E. ; Härtig, W. ; Krügel, U. ; Ueberham, U. ; Arendt, T. ; Illes, P. ; Bringmann, A. ; Reichenbach, A. ; Grosche, Antje
Date of publication of this fulltext: 20 Aug 2014 05:51


Gliosis of retinal Müller glial cells may have both beneficial and detrimental effects on neurons. To investigate the role of purinergic signaling in ischemia-induced reactive gliosis, transient retinal ischemia was evoked by elevation of the intraocular pressure in wild-type (Wt) mice and in mice deficient in the glia-specific nucleotide receptor P2Y1 (P2Y1 receptor-deficient (P2Y1R-KO)). While ...


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