Influence of Fenofibrate treatment on triacylglycerides diacylglycerides and fatty acids in fructose fed rats

URN to cite this document:: urn:nbn:de:bvb:355-epub-307447

Kopf, Thomas ; Schaefer, Hans-Ludwig ; Troetsmueller, Martin ; Koefeler, Harald ; Broenstrup, Mark ; Konovalova, Tatiana ; Schmitz, Gerd

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Date of publication of this fulltext: 11 Sep 2014 13:30

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Abstract

Fenofibrate (FF) lowers plasma triglycerides via PPARα activation. Here, we analyzed lipidomic changes upon FF treatment of fructose fed rats. Three groups with 6 animals each were defined as control, fructose-fed and fructose-fed/FF treated. Male Wistar Unilever Rats were subjected to 10% fructose-feeding for 20 days. On day 14, fenofibrate treatment (100 mg/kg p.o.) was initiated and maintained ...