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Melanocortin 1 receptor-signaling deficiency results in an articular cartilage phenotype and accelerates pathogenesis of surgically induced murine osteoarthritis

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Lorenz, Julia ; Seebach, Elisabeth ; Hackmeyer, Gerit ; Greth, Carina ; Bauer, Richard J. ; Kleinschmidt, Kerstin ; Bettenworth, Dominik ; Böhm, Markus ; Grifka, Joachim ; Grässel, Susanne
Date of publication of this fulltext: 29 Sep 2014 10:40


Proopiomelanocortin-derived peptides exert pleiotropic effects via binding to melanocortin receptors (MCR). MCR-subtypes have been detected in cartilage and bone and mediate an increasing number of effects in diathrodial joints. This study aims to determine the role of MC1-receptors (MC1) in joint physiology and pathogenesis of osteoarthritis (OA) using MC1-signaling deficient mice (Mc1re/e). OA ...


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